Pregneninolone falls in the steroid class of organic compounds. It comes from cholesterol, acting as a building block for the synthesis of various hormones, such as progesterone, cortisol, and other steroids. Its molecular formula is C21H32O2 and on the structural side, the molecule displays a backbone similar to other steroidal compounds. The CAS number associated with Pregneninolone is 145-13-1 and its HS Code, often referenced in shipping and international trade, is 29372900. What people really want to know is how this substance behaves, feels, and looks when handled in a real-world setting.
In everyday handling, Pregneninolone shows up as a white to off-white crystalline solid. Laboratory techs, chemists, and QC staff recognize it by these traits. It can come as powder, flakes, pearls, or crystalline granules. Some batches appear coarse, others seem almost flour-like. The density clocks in at around 1.08 g/cm³. Pregneninolone melts at roughly 191-193 °C. Solubility sets it apart: sparingly soluble in water, more comfortable in alcohol, and prone to disperse in organic solvents like chloroform and dioxane. Certain industries prefer its powder form for ease of measurement, dosing, and blending with other raw materials. In the field, cutting corners with substitutes rarely brings the same results—the structure matters. Whether prepping in a research lab in Paris or a pharmaceutical plant in Beijing, these core characteristics feel consistent.
At the core, Pregneninolone’s structure carries three six-membered rings and one five-membered ring—typical hallmarks of the steroid group. The location of hydroxyl groups and the presence of a ketone function influence its reactivity. Chemists value this molecule for its role as a biochemical precursor. It doesn’t act as a hormone itself, but the body uses it as a starting point, converting it into other hormones people depend on every day. Availability in different grades—research, pharmaceutical, or pure raw material—creates flexibility in use. Structure aside, producers think about purity before anything else. Residual solvents, heavy metals, and microbial loads get tested batch by batch. Even minor impurities can upset batch yields or safety.
Most people working with Pregneninolone use sealed containers, usually dark or amber bottles to keep light and moisture out. One kilogram, five kilogram, or custom packaging gets chosen based on end-use, cost, and safety rules. Labels include warnings—this isn’t something to scatter around the shop floor. Pregneninolone irritates skin and eyes. Prolonged inhalation or unprotected contact brings risks. Chemical safety plays a big part here. MSDS sheets list it as harmful if swallowed or in contact with mucous membranes. Ventilation, gloves, and eye protection draw a clear line between safe work and hazardous exposure. Waste needs proper disposal following chemical waste protocols—nobody wants this stuff near groundwater or regular trash streams.
Raw Pregneninolone comes from plant and animal cholesterol, or via total chemical synthesis. Finished material moves through the life sciences pipeline where it gets used in hormone research, drug synthesis, and sometimes as a reference point in clinical diagnostics. Making sure raw material is consistent batch to batch is no small feat—every manufacturer wants traceable sourcing and clear records. Pharmaceutical outfits need documented origin to comply with stringent rules, while specialty labs focus on the molecular profile first. Multiple industries rely on the substance, ranging from pharmaceuticals through to cosmetics and even agricultural research. Everybody using Pregneninolone in bulk deals with set molecular characteristics, known physical properties, and the unavoidable regulatory paperwork in crossing borders, each step tracked by the HS Code.
Pregneninolone doesn’t pose the highest risk in the chemical world, but even moderate hazards add up in quick-moving settings. Inexperienced workers sometimes skip over correct dose measurement. A few grams miscounted in a blend can derail downstream chemistry and cause failed batches or even small-scale toxicity. In some countries, raw Pregneninolone gets flagged by customs for misuse potential or concern over illegal hormone production. Education serves as a solid answer—every handler, shipper, and lab tech benefits from tailored training sessions explaining not just safety, but also why controls exist. Quality testing fixes another weak point: thorough, regular batch analysis using HPLC, GC-MS, and wet chemistry keeps impurities in check. Labs investing in ventilation upgrades and routine PPE checks avoid long-term exposure complaints. And when it comes to global shipment, digital tracking and clear customs declarations prevent delays and legal snags.
