Product Name: Pregnenolone
Chemical Name: 3β-Hydroxypregn-5-en-20-one
CAS Number: 145-13-1
Molecular Formula: C21H32O2
Molecular Weight: 316.48 g/mol
Synonyms: Delta5-pregnen-3beta-ol-20-one, 3beta-Hydroxy-5-pregnen-20-one
Recommended Use: Pharmaceutical or biochemical research
Manufacturer Details: Supplier contact info and emergency phone listed on request
UN Number: Not assigned or not regulated under UN recommendations
Product Code: Internal batch and lot code available from distributor
Hazard Classification: Not classified as hazardous under GHS guidelines in most countries
Physical Hazards: No significant physical dangers under standard storage and handling
Health Hazards: Dust may irritate mucous membranes, skin, eyes; rare allergic reactions noted in sensitive individuals; endocrine effects possible with repeated exposure
Environmental Hazards: Not classed as an environmental hazard; low aquatic toxicity expected
Signal Word: Not mandatory for this chemical
Hazard Statements: May cause mild irritation upon skin or eye contact; avoid inhalation of dust
Precautionary Statements: Wear protective apparel for skin and eyes; use in well-ventilated areas; minimize creation of dust
Chemical Identity: Pregnenolone (purity >98%)
Impurities: Trace levels of related steroids, solvent residues (handled to pharmaceutical specifications)
Mixture/Single Substance: Single-ingredient product
Other Ingredients: None added
Inhalation: Move to fresh air, rinse mouth with water, seek assistance for persistent symptoms.
Eye Contact: Flush with clean water for at least 15 minutes, remove contact lenses, avoid rubbing eyes.
Skin Contact: Wash with mild soap and water, remove contaminated clothing, seek medical attention if irritation develops.
Ingestion: Rinse mouth, drink water if conscious, consult a healthcare professional if discomfort occurs.
Most Important Symptoms: Mild discomfort or irritation, no known severe acute reactions in healthy adults.
Advice for Medical Personnel: Symptomatic treatment, no specific antidote, monitor for allergic reactions or respiratory distress.
Suitable Extinguishing Media: Use CO2, dry chemical powder, water spray, or foam as appropriate for surrounding fire.
Unsuitable Extinguishing Media: High power water jets may scatter powder.
Combustion Hazards: May release carbon monoxide, carbon dioxide, potentially irritating fumes.
Protective Equipment: Firefighters use self-contained breathing apparatus and protective suits.
Additional Fire Information: Product itself doesn’t readily burn but may contribute to combustion if stored with highly flammable materials.
Personal Precautions: Put on gloves, safety goggles, dust mask if significant powder present.
Environmental Precautions: Prevent entry into water systems and soil where practical.
Methods for Cleanup: Sweep up with care to minimize dust, place in labeled waste container, vacuum residue using HEPA filtration.
Notification Procedures: Notify lab supervisor or spill team; consult local regulations on chemical spill reporting.
Handling: Keep container closed, avoid creating dust clouds, work under fume hood or with proper ventilation.
General Practices: No eating, drinking, or smoking while handling, wash hands after use, avoid direct contact.
Storage Conditions: Store in cool, dry place away from light; temperature between 2°C and 8°C recommended for long-term quality.
Incompatible Products: Strong oxidizers, strong acids.
Container Materials: Use shatterproof glass or HDPE plastic with tight seal.
Shelf Life: At least 2 years under appropriate storage.
Occupational Exposure Limits: No specific regulatory limits set for pregnenolone; follow general nuisance dust standards (OSHA: 15 mg/m³, ACGIH: 10 mg/m³ for particulates)
Engineering Controls: Local exhaust ventilation, fume hood for bulk handling
Personal Protective Equipment (PPE): Nitrile gloves, lab coat, safety goggles, dust mask or respirator if airborne dust generated
Hygiene Measures: Wash hands before leaving work area; avoid skin and eye contact; launder contaminated clothing
Appearance: White to off-white crystalline powder
Odor: Odorless or faint organic smell
Melting Point: 186–190°C
Boiling Point: Decomposes before boiling under atmospheric pressure
Solubility: Slightly soluble in water; freely soluble in ethanol, chloroform, ether
pH: Not applicable as a solid
Vapor Pressure: Extremely low at ambient temperatures
Density: Approximately 1.17 g/cm³
Partition Coefficient (logP): Approx 3.4–3.6
Other Information: Stable under normal laboratory storage conditions; sensitive to light; stable under mild alkaline or acidic environments
Chemical Stability: Stable with proper storage; no rapid breakdown observed under room temperature
Thermal Decomposition: Degrades above 200°C, forms oxides of carbon
Hazardous Reactions: Rare in normal use; may react with strong oxidizers causing decomposition
Conditions to Avoid: High heat, prolonged exposure to intense light, moisture
Incompatible Materials: Strong acids, alkalis, and oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, minor steroid fragments
Routes of Exposure: Inhalation, dermal, ocular, ingestion
Acute Toxicity Data: Low oral and dermal toxicity reported in animal models (rat LD50: above 2000 mg/kg)
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or teratogenicity found in standard tests; hormonal effects possible with repeated exposure
Skin Irritation: Rare mild irritation; prolonged contact not recommended
Eye Irritation: May cause transient discomfort
Inhalation Risks: High dust concentrations cause respiratory discomfort
Sensitization: No confirmed potential for sensitization
Other Data: Endocrine effects at high doses less likely at occupational exposures; target organ toxicity not observed at low levels
Aquatic Toxicity: Low expected toxicity based on structure; rapidly biodegraded
Terrestrial Impact: No significant hazard in small spilled quantities; avoid large-scale contamination
Persistence and Degradability: Likely to biodegrade slowly in soil and water
Bioaccumulative Potential: Low potential predicted
Mobility in Soil: Immobile due to low water solubility; binds to soil particles
Other Effects: Not classified as hazardous to the ecosystem under REACH and GHS
Additional Data: Handle to avoid large releases in natural habitats
Disposal Methods: Collect in labelled waste container, dispose via incineration at an approved facility
Recycling/Reuse: Not advised for pharmaceutical chemicals
Contaminated Packaging: Rinse containers thoroughly, dispose as chemical waste
Regulatory Waste Codes: US EPA RCRA: not listed; refer to local and national legislation
Special Instructions: Keep out of drains, surface water, or natural environments; consult hazardous waste contractor for large volumes
UN Number: Not regulated as dangerous goods for land, air, or sea transport
Proper Shipping Name: Pregnenolone or research chemical (non-hazardous)
Hazard Class: Not applicable
Packing Group: Not assigned
Marine Pollutant: No
Transport Precautions: Protect from moisture, intense heat, and breakage during transit; use sealed containers
Additional Notes: Check local shipping rules for research chemicals as regulations can differ by region
OSHA Hazards: Not considered hazardous under US OSHA criteria
TSCA Listing: Pregnenolone included on inventory
REACH Registration: Exempt as a research chemical for laboratory use under certain thresholds
SARA Title III Sections: Not listed as a reportable chemical
WHMIS (Canada): Not classified as controlled
California Proposition 65: Not listed
Other Regulatory Status: Not controlled as a drug in most countries unless used for manufacturing supplements; check local authorities for intended end use
