Product Name: Pregneninolone
Chemical Formula: C21H32O2
CAS Number: 145-13-1
Synonyms: 3β-Hydroxypregn-5-en-20-one, 5-Pregnen-3β-ol-20-one
Uses: Laboratory chemical, steroid hormone precursor research, pharmaceutical intermediate
Supplier Identification: Manufacturer address, contact telephone number, and emergency contact numbers should be included for any facility storing or handling this compound
Emergency Overview: White to off-white crystalline powder, not combustible under standard conditions, avoid breathing dust
Health Hazards: May cause irritation to eyes, skin, and respiratory tract
Environmental Hazards: Ingredient is not expected to cause long-term adverse effects, spill into ecosystem remains a concern for aquatic life
Warning: Avoid generation of dust, wear protective clothing at all stages of handling
Label Elements: Signal word – Warning, hazard pictograms for irritant
Chemical Name: Pregneninolone
Concentration: 98-100% by weight
Impurities: Trace amounts of related steroid compounds, less than 2% combined
Additives: No diluents, stabilizers, or preservatives reported
Eye Contact: Rinse eyes with running water for at least fifteen minutes, remove contact lenses if present, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, consult doctor if redness or discomfort develops
Inhalation: Move person to fresh air, encourage deep breathing, seek medical advice for coughing or breathing difficulty
Ingestion: Rinse mouth, do not force vomiting, consult a medical professional promptly if large amounts ingested or symptoms of toxicity present
Notes to Physician: Treat symptomatically, no specific antidotes reported for this compound
Suitable Extinguishing Media: Water spray, foam, dry chemical powder, or carbon dioxide works on surrounding fire types
Specific Hazards: Pregneninolone itself will not ignite easily, heated decomposition gives carbon oxides
Protective Equipment: Wear self-contained breathing apparatus and full turn-out gear
Fire Procedures: Avoid inhaling combustion vapors and dust, evacuate area if fire grows beyond control
Personal Precautions: Avoid dust formation, ventilate area, wear lab coat, gloves, and protective eyewear
Environmental Precautions: Keep away from drains, surface water, and soils, decontaminate area after cleanup
Cleanup Methods: Sweep up spilled solid gently, use damp disposable towels for fine residue, segregate waste in a sealed, labeled container for disposal
Handling: Use powder under fume hood where possible, wear respiratory protection if airborne particles form, minimize direct contact
Storage Conditions: Store in tightly closed original container, room temperature or below, avoid sunlight, humidity, and incompatible chemicals like strong oxidizers
Special Considerations: Maintain inventory log, keep storage area uncluttered and access restricted to trained personnel
Occupational Exposure Limits: Not established by OSHA, use good industrial hygiene practices
Engineering Controls: Employ local exhaust ventilation, lab-grade air filtration if possible
Personal Protective Equipment: Nitrile gloves, lab coat or gown, chemical splash goggles, particulate respirator for dusts
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing and clean before reuse
Appearance: White or off-white crystalline powder
Odor: Odorless
Melting Point: 186–188°C
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water, soluble in ethanol, solvents like acetone
Vapor Pressure: Negligible at ambient conditions
Molecular Weight: 316.48 g/mol
Stability: Stable under recommended storage, sensitive to strong acids and oxidizers
pH: Not applicable in solid form
Flash Point: No data, low fire risk as solid
Chemical Stability: Remains stable if kept dry and below 25°C
Incompatibility: Strong oxidizing agents, acids
Decomposition Products: Produces carbon monoxide and carbon dioxide if burned
Polymerization: No hazardous polymerization reported
Acute Toxicity: Oral and dermal toxicity low, not fully studied in humans
Irritation: Can cause mild irritation to skin, eyes, and mucous membranes
Chronic Exposure: No evidence of carcinogenicity or reproductive harm, insufficient long-term study data
Routes of Exposure: Inhalation, skin contact, ingestion
Symptoms: Redness, itching, temporary coughing, headache if excessive exposure occurs
Environmental Fate: Poor solubility in water, potential slow degradation in soils
Bioaccumulation: No significant bioaccumulation expected
Aquatic Effects: No acute aquatic toxicity observed at typical release levels, but minimize discharge
Mobility: Relatively immobile in surface water, binds to soils
Waste Treatment: Collect and dispose as chemical waste according to local, state, and national regulations
Incineration: Safe for incineration at controlled facilities
Container Disposal: Rinse thoroughly, destroy or send to licensed hazardous waste facility
Sewer Disposal: Not allowed, prevent from entering drains or watercourses
Proper Shipping Name: Pregneninolone
UN Number: Not regulated for transportation
Hazard Class: Not classified as dangerous goods
Packing Group: None
Special Precautions: Package tightly sealed, upright, with cushioning to prevent damage during transit
Regulatory Transport: Avoid co-shipment with incompatible chemicals
TSCA Status: Listed for research and development use
EU Regulations: Not subject to REACH registration as isolated intermediate
DSL/NDSL (Canada): Not listed on NDSL
OSHA Hazards: No specific classification, see Section 2 for hazard assessment
Label Requirements: Chemical name, hazard warnings, emergency phone details, storage guidance, intended use
