Product Name: Pregnenedione
Chemical Formula: C21H30O2
Synonyms: 17,20-Dioxopregn-4-en-3-one; Androstadiene-3,17-dione
CAS Number: 566-19-8
Manufacturer: [Manufacturer Name, Address, Emergency Phone Number]
Recommended Use: Laboratory research, pharmaceutical intermediate, hormone synthesis
Restrictions: Not intended for human or veterinary medical use outside of controlled laboratory settings
Hazard Statements: May cause skin and eye irritation, respiratory tract discomfort, reproductive toxicity, and possible endocrine disruption
Signal Word: Warning
GHS Classification: Skin and eye irritant (Category 2), Reproductive toxicity (Category 2)
Pictograms: Exclamation mark, Health hazard
Route of Exposure: Inhalation, skin contact, eye contact, ingestion
Hazard Overview: Symptoms from exposure range from mild skin and eye discomfort to more serious hormonal disruptions if mishandled repeatedly
Chemical Name: Pregnenedione
Concentration: >98% (pure form)
Impurities: Minimal, mainly related steroidal byproducts; none classified as hazardous in standard usage scenarios
Additives: None
Inhalation: Move to fresh air, ensure open breathing passage, consult medical attention if persistent symptoms such as throat irritation or dizziness occur
Skin Contact: Remove contaminated clothing, thoroughly wash skin with soap and water for several minutes, seek medical advice in case of persistent irritation
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present and easy to do, seek medical care for continued eye discomfort
Ingestion: Rinse mouth, avoid inducing vomiting unless instructed by medical professional, seek immediate assistance if larger quantities swallowed
Most Important Symptoms: Irritation of respiratory tract, headaches, possible hormonal effects if exposure is sustained
Special Attention: Individuals with known hormone sensitivity or allergies may face intensified reactions
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards Arising from Chemical: May emit toxic fumes such as oxides of carbon during combustion
Protective Equipment for Firefighters: Standard firefighting gear including self-contained breathing apparatus
Special Firefighting Instructions: Avoid inhalation of combustion products, prevent run-off water contamination
Personal Safety: Wear gloves, eye protection, laboratory coat, use a mask or respirator if dust is generated
Environmental Precautions: Avoid release into drains, surface, and groundwater
Clean-up Methods: Gently sweep up spillage using non-static tools, collect into a closed container, ventilate area, wash affected surfaces with water and neutral cleaner
Disposal: Dispose of collected material according to local hazardous waste regulations
Precautions for Safe Handling: Use only in well-ventilated areas; avoid dust creation; wash thoroughly after handling; keep container tightly closed
Incompatible Materials: Strong oxidizers, acids, strong bases
Storage Conditions: Keep in a cool, dry place below 25°C, protect from light, moisture, and incompatible substances, ensure proper labeling and secure location away from unauthorized access
Engineering Controls: Use local exhaust ventilation, fume hoods, or similar engineering controls to prevent airborne exposure
Personal Protective Equipment (PPE): Nitrile gloves, chemical safety goggles, lab coat, particulate respirator if airborne dust forms
Hygiene Measures: Avoid eating, drinking, or smoking in the work area; wash hands and skin after handling; keep work area clean to reduce accidental exposure
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 175-178°C
Boiling Point: Not available (decomposes before boiling)
Solubility: Poorly soluble in water, soluble in organic solvents like ethanol, chloroform
Density: Approximately 1.1–1.2 g/cm³
pH: Not applicable (insoluble in water)
Vapor Pressure: Negligible at room temperature
Other Data: Stable under standard storage, prone to degradation under strong light or heat
Chemical Stability: Stable when stored appropriately in original containers and recommended conditions
Conditions to Avoid: Excessive heat, direct sunlight, moisture, open flames
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition: May emit noxious gases such as carbon monoxide, carbon dioxide on thermal decomposition
Acute Toxicity: No acute toxicity in animal studies at low doses, though larger quantities may cause symptoms related to endocrine disruption
Skin and Eye Effects: Redness, irritation, discomfort may occur if direct contact happens
Chronic Effects: Prolonged or repeated exposure can disrupt hormonal balance, may impact reproductive health
Inhalation: Dusts may cause sneezing, coughing, or mild respiratory irritation
Carcinogenicity: No data supporting carcinogenic properties
Sensitization: Rare but possible in individuals with steroidal compound allergies
Other Risks: Patients already on steroid therapies or with known endocrine disorders should exercise greater caution
Ecotoxicity: Low in aquatic and terrestrial environments at trace levels, but persistent accumulation could pose risks to aquatic organisms via endocrine disruption
Environmental Persistence: Not easily biodegradable; potential for slow breakdown in soils and sediments
Mobility: Hydrophobic properties limit leaching, but may adsorb to organic material
Bioaccumulation: Possible in organisms with exposure over time
Aquatic Toxicity: Risk to aquatic life in concentrated spills or continuous discharges
Other Environmental Hazards: Possible impact on reproductive cycles of aquatic biota
Disposal Methods: Mix waste with compatible absorbent and place in designated chemical safety containers, incinerate under controlled government-approved conditions, avoid pouring down drains
Packaging Disposal: Empty containers retain residue, treat as hazardous waste, clean only if regulations permit
Special Instructions: Follow local, regional, and national guidelines for hazardous pharmaceutical waste disposal
UN Number: Not classified for transport by UN regulations
Proper Shipping Name: Chemical not regulated under ADR, IMDG, IATA in small laboratory quantities
Hazard Class: None assigned
Packing Group: None applicable
Special Transport Conditions: Avoid damage or leaks, ship in secure, sealed, labeled containers; minimize exposure to incompatible substances and sources of heat
Safety, Health, Environmental Regulations: Subject to chemical handling and workplace safety laws; not scheduled as a controlled substance for transport or primary use, but restrictions may apply for pharmaceutical and research use
Relevant Legislation: OSHA (USA), REACH (EU), WHMIS (Canada), local workplace health and safety codes; check local chemical and workplace regulations
Labeling Requirements: GHS labeling for irritant, reproductive risk
Other Regulatory Notes: Research laboratories must keep inventory logs, Material Safety Data Sheet compliance, and secure storage for all steroidal intermediates
