Product Name: Pregnane-3,20-Dione
Synonyms: 4-Pregnene-3,20-dione, Progesterone, Corpus Luteum Hormone
CAS Number: 57-83-0
Chemical Family: Progestogen Steroid
Recommended Use: Laboratory chemical, pharmaceutical ingredient
Manufacturer: Lab-specific or chemical supplier’s details provided on packaging
GHS Classification: Reproductive toxicity (Category 2), Specific target organ toxicity (single exposure, Category 3)
Label Elements: Signal word: Warning; Hazard statements: Suspected of damaging fertility, May cause drowsiness
Pictogram: Health hazard symbol
Routes of Exposure: Eye contact, skin absorption, inhalation, ingestion
Possible Acute Health Effects: May cause mild irritation to eyes or skin, headache, drowsiness, or dizziness with larger exposures
Chronic Effects: Potential hormone disruption in long-term exposure, possible reproductive toxicity
Environmental Hazard: Potential hazard to aquatic organisms
Chemical: Pregnane-3,20-Dione
Chemical Formula: C21H30O2
Molecular Weight: 314.47 g/mol
Purity: Typically greater than 98% in standard preparations
Impurities: Levels depend on source; may include minor related steroids from synthesis process
Eye Contact: Rinse cautiously with water for several minutes; remove contacts if easy; continue rinsing
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; seek medical attention if irritation persists
Inhalation: Remove person to fresh air; keep at rest in position comfortable for breathing; get medical advice if symptoms develop
Ingestion: Rinse mouth; seek medical advice if large amount swallowed; do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Drowsiness, headache, mild eye or skin irritation, hormonal effects on prolonged exposure
Immediate Medical Attention: Recommended in all cases of significant exposure
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam, or water spray
Unsuitable Extinguishing Media: Straight water streams
Special Hazards: May emit toxic fumes of carbon oxides under fire conditions
Protective Equipment for Firefighters: Self-contained breathing apparatus and full turnout gear
Fire/Explosion Risks: Flammable solid in finely divided form; dust-air mixtures may pose ignition risk; containers may explode when heated
Personal Precautions: Wear appropriate personal protective equipment; avoid breathing dust; ensure adequate ventilation
Environmental Precautions: Prevent further leakage or spillage where safe; do not let product enter drains or waterways
Cleanup Methods: Sweep or vacuum up spilled material using tools that minimize dust generation; transfer to suitable container for disposal; clean contaminated surfaces with water and detergent
Handling: Use only in chemical fume hood; keep away from incompatible materials; minimize dust generation and accumulation; avoid contact with eyes, skin, and clothing; wash hands thoroughly after handling
Storage: Store in tightly closed original container; keep in cool, dry, well-ventilated area; protect from light and moisture
Incompatible Materials: Strong oxidizers, acids, bases
Engineering Controls: Handle within a chemical fume hood; ensure eyewash stations and safety showers are available
Personal Protective Equipment: Chemical-resistant gloves, lab coat, safety goggles, appropriate respiratory protection for dust
Exposure Limits: No occupational exposure limits established by ACGIH or OSHA
Hygiene Measures: Do not eat, drink, or smoke in work area; wash hands after use
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
Melting Point: 126 – 131°C
Boiling Point: Not available due to decomposition
Solubility: Insoluble in water; soluble in acetone, ethanol, chloroform, and ether
Density: 1.17 g/cm³
pH: Not applicable
Flash Point: Not available
Partition Coefficient: log Kow = 3.9 (predicted)
Vapor Pressure: Negligible at room temperature
Chemical Stability: Stable under recommended handling and storage conditions
Hazardous Reactions: May react with strong oxidizing agents
Conditions to Avoid: Excessive heat, open flames, exposure to moisture, and light
Decomposition Products: Carbon oxides under fire conditions
Acute Toxicity: Data on acute oral, dermal, and inhalation toxicity are limited, but low for most laboratory exposures
Skin Corrosion/Irritation: May cause mild irritation after prolonged or repeated contact
Eye Damage/Irritation: Direct contact may result in redness and discomfort
CMR Effects: Suspected of reproductive toxicity; possible hormonal disruption with repeated exposure
Sensitization: Not a known sensitizer
Long-Term Effects: Chronic exposure could disturb hormone balance and reproductive processes
Ecotoxicity: Information is limited, but hormone-active chemicals may cause effects on aquatic life at low concentrations
Persistence and Degradability: May not be readily biodegradable; may persist in the environment
Bioaccumulative Potential: Potential to bioaccumulate in aquatic organisms based on Kow
Mobility in Soil: Limited mobility due to low solubility; tends to adsorb to particulates
Other Adverse Effects: Products with hormonal activity may have effects on aquatic reproduction at trace levels
Waste Treatment Methods: Collect and dispose of contents and container in accordance with local, regional, and national regulations
Handling Contaminated Packaging: Containers should be triple rinsed and disposed through chemical waste stream
Precautions: Do not let material reach domestic sewage or soil
UN Number: Not classified for transport under ADR/RID/IMDG/IATA
Proper Shipping Name: Not regulated
Transport Hazard Class: None assigned
Packing Group: None assigned
Special Precautions: Keep tightly sealed and protected from moisture during transit
US Regulations: Not listed as a hazardous substance under CERCLA, EPCRA, or SARA; TSCA inventory: Yes
EU Regulations: Listed in EINECS; not classified as hazardous under CLP for typical laboratory quantities
DSL/NDSL Status: Listed in Canadian DSL
Other Regulations: Check specific state, provincial, or country requirements for use and disposal; drugs and hormone compounds may require special management
