Product Name: Pregnan-3,20-Dione
Synonyms: Progesterone; 4-Pregnene-3,20-dione
CAS Number: 57-83-0
Recommended Use: Laboratory chemicals, raw material for pharmaceuticals
Manufacturer: [Insert manufacturer name, address, contact info]
Emergency Contact: [Insert emergency telephone number]
Classification: Reproductive toxicity (Category 2); Skin sensitizer (Category 1B); Not classified as highly flammable or explosive
Signal Word: Warning
Hazard Statements: Suspected of damaging fertility; May cause an allergic skin reaction
Pictograms: Health hazard, exclamation mark
Precautionary Statements: Avoid breathing dust; Wash hands thoroughly after use; Wear protective gloves; Use in ventilated area
Other Hazards: Dust may cause respiratory irritation or mild irritation to eyes
Chemical Identity: Progesterone
Concentration: 98-100%
Molecular Formula: C21H30O2
Molecular Weight: 314.5 g/mol
Impurities: Trace residual solvents, minor related steroids (if not purified)
Inhalation: Move victim to fresh air, monitor breathing, seek medical advice if symptoms persist
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; seek medical attention for irritation
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; get medical attention if discomfort continues
Ingestion: Do not induce vomiting; rinse mouth with water; consult a physician
Most Important Symptoms: Allergic reaction, respiratory tract irritation, possible hormonal effects on long-term exposure
Suitable Extinguishing Media: Use CO2, dry chemical, alcohol foam, or water spray
Unsuitable Media: High-pressure water jets
Special Hazards: Carbon monoxide, carbon dioxide, potentially toxic fumes upon combustion
Firefighter Precautions: Wear self-contained breathing apparatus and full protective clothing; avoid inhaling smoke/fumes
Other Advice: Move containers away if safe to approach; stay upwind; potential dust explosion if fine powder disperses
Personal Precautions: Avoid breathing dust; ventilate area; use suitable PPE including gloves and dust mask
Environmental Precautions: Prevent entry into sewers and waterways; contain spill by covering with absorbent material
Cleanup Methods: Collect using damp cloth or vacuum with HEPA filter; transfer to secure, labeled waste container; wash spill site with soap and water once material is picked up
Other Recommendations: Dispose of all contaminated material in accordance with local regulations; report large spills to proper authorities
Handling: Open containers carefully; minimize dust generation; avoid direct contact with skin or eyes; keep away from sources of ignition; do not eat, drink, or smoke during use
General Hygiene: Wash hands thoroughly after handling; remove contaminated clothing and wash before reuse
Storage: Keep containers tightly closed in a cool, dry, well-ventilated place; protect from light and moisture; store away from incompatible materials such as oxidizers or strong acids
Special Requirements: Secure storage with access limited to qualified personnel; labeled clearly as a hormone with restricted use
Exposure Limits: No established occupational exposure limits for progesterone; minimize exposure as much as possible
Engineering Controls: Use fume hood or local exhaust; maintain general ventilation
Personal Protective Equipment: Nitrile or latex gloves, safety glasses with side shields, lab coat or disposable coverall
Respiratory Protection: Dust mask or respirator with P2 filter if handling large quantities or powder form
Hygienic Measures: Avoid inhaling, eating, drinking, or smoking in area; remove PPE before leaving work area
Appearance: White or off-white crystalline powder
Odor: Odorless or faint characteristic odor
Melting Point: 126–131 °C
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water, soluble in ethanol, methanol, chloroform, dioxane
Vapor Pressure: Not significant at room temperature
Density: 1.17–1.2 g/cm³
Partition Coefficient (log Kow): Approximately 3.9
pH (aqueous solution): Not applicable
Flash Point: >150 °C (closed cup)
Auto-ignition Temperature: Not determined
Explosive Properties: Dust can form explosive mixtures in air under certain conditions
Chemical Stability: Stable at room temperature under normal handling and storage conditions
Reactivity: Low under recommended conditions
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, other toxic fumes
Conditions to Avoid: Heat, open flame, moisture, direct sunlight, incompatible substances
Polymerization: Not expected under normal conditions
Acute Toxicity: LD50 (oral, rat): >3000 mg/kg (low toxicity); considered safe in therapeutic doses
Routes of Exposure: Inhalation, skin, eye, ingestion
Symptoms of Exposure: Irritation to mucous membranes, possible skin sensitization, endocrine effects (menstrual disturbances, mood change, prolonged exposure risk)
Carcinogenicity: Not classified as carcinogenic
Reproductive Effects: Suspected of effects on fertility, may disrupt hormone balance
Other Effects: Long-term occupational exposure can cause hormonal symptoms in sensitive individuals
Toxicity to Aquatic Life: Data limited, but hormones in water can affect aquatic species
Persistence and Degradability: Slowly biodegradable; resists breakdown in environment
Bioaccumulation Potential: Moderate; log Kow suggests potential for accumulation in aquatic organisms
Mobility in Soil: Low mobility due to low water solubility; binds to soil particles
Other Environmental Hazards: Avoid uncontrolled release; possible endocrine effects on wildlife at low concentrations
Waste Treatment Methods: Dispose as hazardous pharmaceutical waste; use approved incineration facility or licensed chemical disposal company
Contaminated Packaging: Should also be incinerated or sent to authorized landfill according to regulations
Do Not: Release into drains, surface water, or soil
Disposal Regulations: Follow all local, regional, and national regulations for disposal of hormone pharmaceuticals
UN Number: Not regulated for transport under most systems (IATA, IMDG, ADR)
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: None
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions: Transport in tightly closed, labeled containers; protect from moisture and physical damage
EU Regulation: Classified under REACH as substance of very high concern due to reproductive toxicity
US Regulation: Not specifically listed in TSCA inventory, but falls under pharmaceutical control laws; OSHA hazard communication applies
Labeling Requirements: Hazard label with fertility warning, skin sensitizer pictogram, precautionary measures
Other National Inventories: Compliance with Canada DSL, Australia AICS, Japan ENCS as relevant
Workplace Controls: Subject to occupational exposure monitoring and medical surveillance where required
Other Notes: Product use restricted to authorized professionals and licensed laboratories; safety training for hormone hazards advised
