Product Name: Allopregnanolone
SYNONYMS: 3α-Hydroxy-5α-pregnan-20-one, 5α-Pregnan-3α-ol-20-one
CAS Number: 566-65-8
Recommended Uses: Neurological research, laboratory chemical
Manufacturer Details: Please refer to label or supplier for contact information
Emergency Contact: Local Poison Control Center, medical emergency services, or chemical hazard hotlines
GHS Classification: Not classified as hazardous according to GHS standards
Health Hazards: May cause mild skin or eye irritation in sensitive individuals. Dust inhalation can cause discomfort in the respiratory tract. Accidental ingestion may lead to stomach upset.
Environmental Hazards: Not expected to be harmful to aquatic environments under normal laboratory usage.
Signal Word: No signal word required
Hazard Statements: Not expected to present health hazards under normal handling. Avoid unnecessary contact or inhalation of dust.
Chemical Name: Allopregnanolone
Molecular Formula: C21H34O2
Molecular Weight: 318.5 g/mol
Concentration: 100% pure (unless otherwise diluted by end user)
Impurities: No documented hazardous impurities
Additives: None unless otherwise stated on supply label
Inhalation: Remove person to fresh air. Seek medical attention if symptoms persist.
Skin Contact: Wash thoroughly with mild soap and water. Seek attention for skin irritation.
Eye Contact: Rinse gently with plenty of water. Remove contact lenses. Continue rinsing if discomfort persists.
Ingestion: Rinse mouth with water. Seek medical advice. Keep person comfortable; do not induce vomiting.
Most Important Symptoms: Mild irritant symptoms possible in rare cases.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, or foam
Specific Hazards: May emit toxic fumes during combustion (CO, CO2)
Advice for Firefighters: Wear self-contained breathing apparatus (SCBA), gloves, and protective clothing
Protective Equipment: Isolate area and remove personnel. Cool containers with water spray from a safe distance.
Personal Precautions: Wear appropriate protective equipment such as gloves and goggles.
Spill Response: Sweep or scoop up solid material without generating dust. For liquids, absorb with inert material.
Containment: Prevent entry into drains or watercourses.
Cleanup Methods: Gather material in clearly labeled container for disposal. Ventilate area well.
Handling: Use in a ventilated area with gloves and eye protection. Avoid dust generation or inhalation.
Storage Conditions: Store in a tightly sealed container, away from heat, direct sunlight, and moisture.
Incompatible Materials: Strong oxidizers, strong acids.
Storage Temperature: Room temperature or cooler, away from sources of ignition.
Exposure Limits: Not established for Allopregnanolone.
Engineering Controls: Use fume hood or local exhaust ventilation.
Personal Protective Equipment: Safety goggles, chemical-resistant gloves, laboratory coat. Dust mask recommended during powder handling.
Hygiene Measures: Wash hands thoroughly after use. Do not eat, drink, or smoke during handling.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not available
pH: Not applicable
Melting Point/Freezing Point: 162–164°C
Boiling Point: Not determined
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible at room temperature
Solubility: Practically insoluble in water; soluble in organic solvents (ethanol, DMSO)
Partition Coefficient (log Pow): Estimated high
Decomposition Temperature: >200°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Avoid exposure to strong acids, bases, and oxidizing agents
Possibility of Hazardous Reactions: No dangerous reactions expected under normal conditions
Hazardous Decomposition Products: Carbon oxides possible on burning or decomposition
Acute Toxicity: No acute toxicity data available; generally considered low toxicity
Skin Corrosion/Irritation: Might cause mild irritation for sensitive skin
Eye Damage/Irritation: Possible mild irritation
Respiratory or Skin Sensitization: No known sensitization effects
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Mutagenicity: No mutagenicity data present
Reproductive Toxicity: No evidence of reproductive hazard under normal laboratory handling
Potential Health Effects: Unlikely unless exposure is prolonged or at high levels outside normal lab use
Ecotoxicity: Not expected to present acute danger to aquatic life
Persistence and Degradability: Limited information; likely to undergo slow biodegradation
Bioaccumulative Potential: Likely to be low due to lipophilicity and low solubility
Mobility in Soil: Low mobility in soil and water environments
Other Adverse Effects: No significant environmental effects recognized in context of controlled lab use
Disposal Methods: Send to an approved chemical disposal firm. Do not release into environment or regular waste stream.
Contaminated Packaging: Treat as hazardous material; dispose of via chemical waste containers.
Local Regulations: Must follow local, state, and national regulations for chemical waste.
Special Precautions: Label all waste for tracking and safety.
UN Number: Not regulated
UN Proper Shipping Name: Chemical substance, not otherwise specified
Transport Hazard Class: Not classified as hazardous
Packing Group: Not assigned
Environmental Hazards: No known environmental risks during transport
Transport in Bulk: Not applicable for product form
Special Precautions: Handle in sealed containers; protect from physical damage or moisture
US TSCA: Listed
EU EINECS / ELINCS: Listed
REACH Status: Product not subject to REACH registration for laboratory research use
SARA Title III: Not listed as hazardous
California Proposition 65: Not listed
Other Regulatory Listings: Check with local, state, and international agencies for specific handling requirements
Labeling: Labelling should include clear identification of substance, hazard, and handling recommendations
