Product Name: 4-Pregnene-3,20-Dione
Synonyms: Progesterone, Corpus luteum hormone, P4
CAS Number: 57-83-0
Recommended Use: Hormonal medication, research chemical, biochemical studies
Manufacturer: Pharmacy or chemical supplier; address information found on label
Emergency Contact: Refer to local poison control center or product supplier contact
Chemical Formula: C21H30O2
GHS Classification: Reproductive toxicity (Category 2), Specific target organ toxicity (Category 2), Skin irritation (Category 3)
Signal Word: Warning
Hazard Symbols: Exclamation mark, health hazard pictogram
Hazard Statements: Suspected of damaging fertility or the unborn child. Causes mild skin irritation. May cause harm to breast-fed children. Irritating to eyes, skin, and respiratory tract. Dust formation may aggravate symptoms.
Precautionary Statements: Wear protective clothing. Avoid release to the environment. Wash hands thoroughly after handling. Do not handle until all safety precautions have been read and understood.
Chemical Identity: 4-Pregnene-3,20-Dione (Progesterone)
Concentration: 98-100%
Impurities: Traces of other steroidal byproducts, inert processing residues
CAS Number: 57-83-0
EC Number: 200-350-6
Molecular Weight: 314.47 g/mol
Inhalation: Move person to fresh air. Avoid breathing dust. Seek medical advice if symptoms such as cough or shortness of breath develop.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with plenty of water and soap. Seek medical attention if redness or irritation persists.
Eye Contact: Rinse eyes with gentle stream of water for at least 15 minutes, lifting eyelids occasionally. Remove contact lenses if present. Get medical attention if symptoms worsen.
Ingestion: Rinse mouth thoroughly. Drink several cups of water if alert, do not induce vomiting unless instructed by medical personnel. Obtain immediate medical assistance.
Note to Physicians: Treat symptomatically. Monitor for respiratory or allergic reactions. Provide supportive care as required.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray. Choose method appropriate for surrounding area.
Unsuitable Extinguishing Media: Direct water jet may spread powder or cause splatter.
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, possibly irritating fumes and smoke
Special Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear. Avoid breathing smoke or vapors.
Fire or Explosion Hazards: Fine dust may form explosive mixtures in air. Avoid creating dust clouds. Keep containers cool with water spray if exposed to fire.
Personal Precautions: Use personal protective equipment. Avoid breathing dust or contact with eyes/skin.
Containment: Prevent further leakage or spillage if safe to do so. Avoid run off into drains, surface water, or soil.
Cleanup Methods: Scoop or sweep carefully to avoid raising dust. Collect in suitable, labeled containers for disposal. Wipe area with damp cloth to remove residues.
Environmental Precautions: Spilled material can affect aquatic organisms. Do not flush into sewers or waterways.
Handling: Handle in a well-ventilated area or chemical fume hood. Minimize dust generation and accumulation. Use appropriate PPE such as gloves, safety glasses, and lab coat. After handling, wash hands and exposed skin thoroughly.
Storage: Store in tightly closed, clearly labeled containers in a cool, dry, ventilated area. Protect from light, heat, humidity, and incompatible materials such as strong acids and bases. Segregate from food and drink. Keep out of reach of children.
Exposure Limits: No established occupational exposure limits. Handle as a potential reproductive hazard.
Engineering Controls: Use local exhaust or mechanical ventilation for dust control. Maintain eyewash stations and safety showers in work area.
Personal Protection: Wear protective gloves (nitrile or PVC), chemical-resistant goggles, laboratory coat, and, if dust risk exists, an approved particulate respirator. Remove and wash contaminated clothing before reuse.
Hygiene Measures: Change work clothes often, and do not eat, drink, or smoke in the work area. Wash hands after handling.
Appearance: White or nearly white crystalline powder
Odor: Odorless or faintly perceptible odor
Melting Point: 126-131°C
Boiling Point: Decomposes before boiling; not determined
Solubility in Water: Practically insoluble
Solubility in Other Solvents: Soluble in alcohol, chloroform, dioxane, acetone, ethyl acetate, oils
pH: Not applicable (insoluble in water)
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.13 g/cm³
Partition Coefficient (log Pow): 3.87
Flash Point: Not available; dusts may pose explosion risk
Chemical Stability: Stable under recommended storage and use conditions. Sensitive to light and air over extended periods.
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Conditions to Avoid: High temperature, moisture, direct sunlight, ignition sources
Hazardous Decomposition Products: Thermal decomposition releases carbon monoxide, carbon dioxide, possibly some irritating fumes
Polymerization: Not expected under normal handling. No dangerous polymerization reported.
Acute Toxicity: Low acute toxicity in animal studies. Oral LD50 in rat >3000 mg/kg.
Routes of Exposure: Inhalation, ingestion, dermal, eye contact
Symptoms: Irritation of eyes, skin, respiratory passages; large doses may disrupt hormone balance, trigger allergic or reproductive effects.
Chronic Effects: Potential to cause menstrual disturbances, changes in reproductive organs or fertility, effects on embryo/fetus.
Carcinogenicity: Not listed as human carcinogen by IARC, NTP, OSHA
Mutagenicity: No significant findings reported
Reproductive Effects: Animal studies show possible reproductive toxicity. Exposure affects fertility and may impact fetal development.
Ecotoxicity: Progesterone may disrupt aquatic life hormone balance, particularly at higher concentrations.
Aquatic Toxicity: Harmful to aquatic organisms even in low quantities. Limited direct data, but endocrine-disrupting potential impacts ecology.
Persistence and Degradability: Not readily biodegradable. Persists in soil and sediments, decomposes slowly.
Bioaccumulation: May accumulate in aquatic species due to lipid solubility.
Mobility: Absorbed to soil particles; limited mobility in ground water
Other Adverse Effects: Contamination can lead to hormone disruption in wildlife.
Waste Disposal: Dispose of in accordance with local, regional, national, or international regulations. Do not pour into drains, waterways, or regular trash. Small quantities can be diluted and incinerated in a chemical waste incinerator. Larger quantities require licensed hazardous waste contractor.
Contaminated Packaging: Treat empty containers as hazardous. Triple rinse before recycling or disposal. Properly label and seal packaging.
Special Considerations: Keep away from food, water supplies, and uncontrolled environments.
UN Number: Not regulated as dangerous goods by IATA, DOT, or IMDG
Shipping Name: 4-Pregnene-3,20-Dione, Progesterone
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Ship in strong, sealed packaging. Follow regulations for pharmaceuticals and lab chemicals.
US Regulations: Not listed as hazardous by OSHA. Reportable quantity not established. Subject to FDA and DEA regulations as a prescription hormone.
European Regulations: Listed on EINECS/ELINCS. Classified under REACH as a potential reproductive toxin.
WHMIS (Canada): D2A (very toxic), D2B (toxic)
TSCA: Complies with TSCA regulations.
Other Regulations: Dispose according to national or regional laws. Follow laboratory safety regulations at all times.
Labeling Requirements: Clearly mark as hormone/chemical dust, avoid exposure, and warn of reproductive effects.
